B.R.A.I.N.
PUBLICATIONS
Explore a curated collection of peer-reviewed articles, conference papers, and other academic works showcasing our innovative discoveries and advancements in the field.
2024
Gargano, M. A., Matentzoglu, N., Coleman, B., Addo-Lartey, E. B., Anagnostopoulos, A. V., Anderton, J., Avillach, P., Bagley, A. M., Bakštein, E., Balhoff, J. P., Baynam, G., Bello, S. M., Berk, M., Bertram, H., Bishop, S., Blau, H., Bodenstein, D. F., Botas, P., Boztug, K., … Robinson, P. N. (2023). The Human Phenotype Ontology in 2024: phenotypes around the world. Nucleic Acids Research. https://doi.org/10.1093/nar/gkad1005
Gonzalez-Torres, C., Mulsant, B. H., Husain, M. I., Alda, M., Young, R. C., & Ortiz, A. (2023). Challenges in defining treatment-resistant mania in adults: A systematic review. Bipolar Disorders. https://doi.org/10.1111/bdi.13383
Ortiz, A., Park, Y., MacLean, S., Husain, M. I., Sanches, M., Ravindran, A., & Mulsant, B. H. (2023). A history of suicide attempt is associated with increased sympathetic activation in bipolar disorder. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie, 7067437231194334. https://doi.org/10.1177/07067437231194334
2023
Dang, K., Ritvo, P., Katz, J., Gratzer, D., Knyahnytska, Y., Ortiz, A., Walters, C., Attia, M., Gonzalez-Torres, C., Lustig, A., & Daskalakis, Z. (2023). The role of daily steps in the treatment of major depressive disorder: Secondary analysis of a randomized controlled trial of a 6-month internet-based, mindfulness-based cognitive behavioral therapy intervention for youth. Interactive Journal of Medical Research, 12, e46419. https://doi.org/10.2196/46419
Halabi, R., Gonzalez-Torres, C., MacLean, S., Husain, M. I., Pratap, A., Alda, M., Mulsant, B. H., & Ortiz, A. (2023). A new approach to assess postural dynamics and its association with higher illness burden in bipolar disorder. https://doi.org/10.36227/techrxiv.23261975.v1
Husain, M. I., Blumberger, D. M., Castle, D. J., Ledwos, N., Fellows, E., Jones, B. D. M., Ortiz, A., Kloiber, S., Wang, W., Rosenblat, J. D., & Mulsant, B. H. (2023). Psilocybin for treatment-resistant depression without psychedelic effects: study protocol for a 4-week, double-blind, proof-of-concept randomised controlled trial. BJPsych Open, 9(4), e134. https://doi.org/10.1192/bjo.2023.535
Jones, B. D. M., Fernandes, B. S., Husain, M. I., Ortiz, A., Rajji, T. K., Blumberger, D. M., Butters, M. A., Gildengers, A. G., Shablinski, T., Voineskos, A., & Mulsant, B. H. (2023). A cross-sectional study of cognitive performance in bipolar disorder across the lifespan: the cog-BD project. Psychological Medicine, 53(13), 6316–6324. https://doi.org/10.1017/S0033291722003622
Jones, B. D. M., Mahmood, U., Hodsoll, J., Chaudhry, I. B., Khoso, A. B., Husain, M. O., Ortiz, A., Husain, N., Mulsant, B. H., Young, A. H., & Husain, M. I. (2023). Associations between peripheral inflammation and clinical phenotypes of bipolar depression in a lower-middle income country. CNS Spectrums, 28(6), 710–718. https://doi.org/10.1017/S1092852923002316
Jones, B. D. M., Umer, M., Kittur, M. E., Finkelstein, O., Xue, S., Dimick, M. K., Ortiz, A., Goldstein, B. I., Mulsant, B. H., & Husain, M. I. (2023). A systematic review on the effectiveness of dialectical behavior therapy for improving mood symptoms in bipolar disorders. International Journal of Bipolar Disorders, 11(1), 6. https://doi.org/10.1186/s40345-023-00288-6
Jones, B. D. M., Zhukovsky, P., Hawco, C., Ortiz, A., Cipriani, A., Voineskos, A. N., Mulsant, B. H., & Husain, M. I. (2023). Protocol for a systematic review and meta-analysis of coordinate-based network mapping of brain structure in bipolar disorder across the lifespan. BJPsych Open, 9(6), e178. https://doi.org/10.1192/bjo.2023.569
Multi-resolution Time-frequency Spectral Derivative Spike Detection for Episode Onset Detection using Passively Collected Sensor Data. (n.d.).
Ortiz, A., Park, Y., Gonzalez-Torres, C., Alda, M., Blumberger, D. M., Burnett, R., Husain, M. I., Sanches, M., & Mulsant, B. H. (2023). Predictors of adherence to electronic self-monitoring in patients with bipolar disorder: a contactless study using Growth Mixture Models. International Journal of Bipolar Disorders, 11(1), 18. https://doi.org/10.1186/s40345-023-00297-5
2022
Cullen, C., Kappelmann, N., Umer, M., Abdolizadeh, A., Husain, M. O., Bonato, S., Sharma, G., Xue, S., Ortiz, A., Kloiber, S., Mulsant, B., & Husain, M. I. (2022). P199. Efficacy and acceptability of pharmacotherapy for comorbid anxiety symptoms in bipolar disorder: A systematic review and meta-analysis. Biological Psychiatry, 91(9), S167–S168. https://doi.org/10.1016/j.biopsych.2022.02.433
Jones, B., Mahmood, U., Hodsoll, J., Chaudhry, I., Khoso, A. B., Husain, M. O., Ortiz, A., Husain, N., Mulsant, B., Young, A., & Husain, M. I. (2022). P180. The association between peripheral inflammation and symptoms of bipolar depression in a lower-middle income country. Biological Psychiatry, 91(9), S159–S160. https://doi.org/10.1016/j.biopsych.2022.02.414
Kloiber, S., Jones, B. D. M., Hodsoll, J., Chaudhry, I. B., Khoso, A. B., Omair Husain, M., Ortiz, A., Goldstein, B. I., Husain, N., Mulsant, B. H., Young, A. H., & Ishrat Husain, M. (2022). Metabolic function in patients with bipolar depression receiving anti-inflammatory agents: Findings from the MINDCARE study, a multicentre, randomised controlled trial. Journal of Affective Disorders, 299, 135–141. https://doi.org/10.1016/j.jad.2021.11.032
Konstantinou, G., Hui, J., Ortiz, A., Kaster, T. S., Downar, J., Blumberger, D. M., & Daskalakis, Z. J. (2022). Repetitive transcranial magnetic stimulation (rTMS) in bipolar disorder: A systematic review. Bipolar Disorders, 24(1), 10–26. https://doi.org/10.1111/bdi.13099
Nunes, A., Singh, S., Allman, J., Becker, S., Ortiz, A., Trappenberg, T., & Alda, M. (2022). A critical evaluation of dynamical systems models of bipolar disorder. Translational Psychiatry, 12(1), 416. https://doi.org/10.1038/s41398-022-02194-4
Ortiz, A., Bradler, K., Moorti, P., MacLean, S., Ishrat Husain, M., Sanches, M., Goldstein, B. I., Alda, M., & Mulsant, B. H. (2022). Increased sympathetic tone is associated with illness burden in bipolar disorder. Journal of Affective Disorders, 297, 471–476. https://doi.org/10.1016/j.jad.2021.10.089
Ortiz, A., Hintze, A., Burnett, R., Gonzalez-Torres, C., Unger, S., Yang, D., Miao, J., Alda, M., & Mulsant, B. H. (2022). Identifying patient-specific behaviors to understand illness trajectories and predict relapses in bipolar disorder using passive sensing and deep anomaly detection: protocol for a contactless cohort study. BMC Psychiatry, 22(1), 288. https://doi.org/10.1186/s12888-022-03923-1
Ortiz, A., Sanches, M., Abdelhack, M., Schwaiger, T. R., Wainberg, M., Tripathy, S. J., Felsky, D., Mulsant, B. H., & Fiedorowicz, J. G. (2022). Sex-specific associations between lifetime diagnosis of bipolar disorder and cardiovascular disease: A cross-sectional analysis of 257,673 participants from the UK Biobank. Journal of Affective Disorders, 319, 663–669. https://doi.org/10.1016/j.jad.2022.09.048
Phillips, J. L., Van Geel, A., Burhunduli, P., Vasudev, D., Batten, L. A., Norris, S., Talbot, J., Ortiz, A., Owoeye, O., & Blier, P. (2022). Assessment of objective and subjective cognitive function in patients with treatment-resistant depression undergoing repeated ketamine infusions. The International Journal of Neuropsychopharmacology, 25(12), 992–1002. https://doi.org/10.1093/ijnp/pyac045
Ritvo, P., Gratzer, D., Knyahnytska, Y., Ortiz, A., Walters, C., Katz, J., Laposa, J., Baldissera, C., Wayne, N., Pfefer-Litman, D., Tomlinson, G., & Daskalakis, Z. (2022). Comparing online and on-site cognitive behavior therapy in major depressive disorder: Protocol for a noninferiority randomized controlled trial. JMIR Research Protocols, 11(4), e29726. https://doi.org/10.2196/29726
2021
Cullen, C., Kappelmann, N., Umer, M., Abdolizadeh, A., Husain, M. O., Bonato, S., Sharma, G., Xue, S., Ortiz, A., Kloiber, S. M., Mulsant, B. H., & Husain, M. I. (2021). Efficacy and acceptability of pharmacotherapy for comorbid anxiety symptoms in bipolar disorder: A systematic review and meta-analysis. Bipolar Disorders, 23(8), 754–766. https://doi.org/10.1111/bdi.13125
Kalman, J. L., Olde Loohuis, L. M., Vreeker, A., McQuillin, A., Stahl, E. A., Ruderfer, D., Grigoroiu-Serbanescu, M., Panagiotaropoulou, G., Ripke, S., Bigdeli, T. B., Stein, F., Meller, T., Meinert, S., Pelin, H., Streit, F., Papiol, S., Adams, M. J., Adolfsson, R., Adorjan, K., … Ophoff, R. A. (2021). Characterisation of age and polarity at onset in bipolar disorder. The British Journal of Psychiatry: The Journal of Mental Science, 219(6), 659–669. https://doi.org/10.1192/bjp.2021.102
Ortiz, A., Husain, I., Moorti, P., Alda, M., Sanches, M., & Mulsant, B. (2021). Higher illness burden is associated with reduced heart rate variability in bipolar disorder. European Psychiatry: The Journal of the Association of European Psychiatrists, 64(S1), S76–S77. https://doi.org/10.1192/j.eurpsy.2021.233
Ortiz, Abigail, Bradler, K., Moorti, P., MacLean, S., Husain, M. I., Sanches, M., Goldstein, B. I., Alda, M., & Mulsant, B. H. (2021). Reduced heart rate variability is associated with higher illness burden in bipolar disorder. Journal of Psychosomatic Research, 145(110478), 110478. https://doi.org/10.1016/j.jpsychores.2021.110478
Ortiz, Abigail, Bradler, K., Mowete, M., MacLean, S., Garnham, J., Slaney, C., Mulsant, B. H., & Alda, M. (2021). The futility of long-term predictions in bipolar disorder: mood fluctuations are the result of deterministic chaotic processes. International Journal of Bipolar Disorders, 9(1), 30. https://doi.org/10.1186/s40345-021-00235-3
Ortiz, Abigail, Maslej, M. M., Husain, M. I., Daskalakis, Z. J., & Mulsant, B. H. (2021). Apps and gaps in bipolar disorder: A systematic review on electronic monitoring for episode prediction. Journal of Affective Disorders, 295, 1190–1200. https://doi.org/10.1016/j.jad.2021.08.140
Robba, C., Graziano, F., Rebora, P., Elli, F., Giussani, C., Oddo, M., Meyfroidt, G., Helbok, R., Taccone, F. S., Prisco, L., Vincent, J.-L., Suarez, J. I., Stocchetti, N., Citerio, G., & SYNAPSE-ICU Investigators. (2021). Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study. Lancet Neurology, 20(7), 548–558. https://doi.org/10.1016/S1474-4422(21)00138-1
2020
Burdick, K. E., Millett, C. E., Russo, M., Alda, M., Alliey-Rodriguez, N., Anand, A., Balaraman, Y., Berrettini, W., Bertram, H., Calabrese, J. R., Calkin, C., Conroy, C., Coryell, W., DeModena, A., Feeder, S., Fisher, C., Frazier, N., Frye, M., Gao, K., … Kelsoe, J. R. (2020). The association between lithium use and neurocognitive performance in patients with bipolar disorder. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 45(10), 1743–1749. https://doi.org/10.1038/s41386-020-0683-2
Husain, M. I., Cullen, C., Umer, M., Carvalho, A. F., Kloiber, S., Meyer, J. H., Ortiz, A., Knyahnytska, Y., Husain, M. O., Giddens, J., Diniz, B. S., Wang, W., Young, A. H., Mulsant, B. H., & Daskalakis, Z. J. (2020). Minocycline as adjunctive treatment for treatment-resistant depression: study protocol for a double blind, placebo-controlled, randomized trial (MINDEP2). BMC Psychiatry, 20(1), 173. https://doi.org/10.1186/s12888-020-02553-9
Kloiber, S., Rosenblat, J. D., Husain, M. I., Ortiz, A., Berk, M., Quevedo, J., Vieta, E., Maes, M., Birmaher, B., Soares, J. C., & Carvalho, A. F. (2020). Neurodevelopmental pathways in bipolar disorder. Neuroscience and Biobehavioral Reviews, 112, 213–226. https://doi.org/10.1016/j.neubiorev.2020.02.005
Ortiz, A., Bradler, K., Garnham, J., Slaney, C., MacLean, S., & Alda, M. (2020). Mood variability in bipolar disorder patients and their unaffected first-degree relatives. Biological Psychiatry, 87(9), S309–S310. https://doi.org/10.1016/j.biopsych.2020.02.798
Phillips, J. L., Norris, S., Talbot, J., Birmingham, M., Hatchard, T., Ortiz, A., Owoeye, O., Batten, L. A., & Blier, P. (2020). Single, repeated, and maintenance ketamine infusions for treatment-resistant depression: A randomized controlled trial. Focus (American Psychiatric Publishing), 18(2), 236–243. https://doi.org/10.1176/appi.focus.18206
Phillips, J. L., Norris, S., Talbot, J., Hatchard, T., Ortiz, A., Birmingham, M., Owoeye, O., Batten, L. A., & Blier, P. (2020). Single and repeated ketamine infusions for reduction of suicidal ideation in treatment-resistant depression. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 45(4), 606–612. https://doi.org/10.1038/s41386-019-0570-x
Xue, S., Husain, M. I., Ortiz, A., Husain, M. O., Daskalakis, Z. J., & Mulsant, B. H. (2020). COVID-19: Implications for bipolar disorder clinical care and research. SAGE Open Medicine, 8, 2050312120981178. https://doi.org/10.1177/2050312120981178
2019
Gargano, M. A., Matentzoglu, N., Coleman, B., Addo-Lartey, E. B., Anagnostopoulos, A. V., Anderton, J., Avillach, P., Bagley, A. M., Bakštein, E., Balhoff, J. P., Baynam, G., Bello, S. M., Berk, M., Bertram, H., Bishop, S., Blau, H., Bodenstein, D. F., Botas, P., Boztug, K., … Robinson, P. N. (2023). The Human Phenotype Ontology in 2024: phenotypes around the world. Nucleic Acids Research. https://doi.org/10.1093/nar/gkad1005
Gonzalez-Torres, C., Mulsant, B. H., Husain, M. I., Alda, M., Young, R. C., & Ortiz, A. (2023). Challenges in defining treatment-resistant mania in adults: A systematic review. Bipolar Disorders. https://doi.org/10.1111/bdi.13383
Ortiz, A., Park, Y., MacLean, S., Husain, M. I., Sanches, M., Ravindran, A., & Mulsant, B. H. (2023). A history of suicide attempt is associated with increased sympathetic activation in bipolar disorder. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie, 7067437231194334. https://doi.org/10.1177/07067437231194334
2018
Gargano, M. A., Matentzoglu, N., Coleman, B., Addo-Lartey, E. B., Anagnostopoulos, A. V., Anderton, J., Avillach, P., Bagley, A. M., Bakštein, E., Balhoff, J. P., Baynam, G., Bello, S. M., Berk, M., Bertram, H., Bishop, S., Blau, H., Bodenstein, D. F., Botas, P., Boztug, K., … Robinson, P. N. (2023). The Human Phenotype Ontology in 2024: phenotypes around the world. Nucleic Acids Research. https://doi.org/10.1093/nar/gkad1005
Gonzalez-Torres, C., Mulsant, B. H., Husain, M. I., Alda, M., Young, R. C., & Ortiz, A. (2023). Challenges in defining treatment-resistant mania in adults: A systematic review. Bipolar Disorders. https://doi.org/10.1111/bdi.13383
Ortiz, A., Park, Y., MacLean, S., Husain, M. I., Sanches, M., Ravindran, A., & Mulsant, B. H. (2023). A history of suicide attempt is associated with increased sympathetic activation in bipolar disorder. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie, 7067437231194334. https://doi.org/10.1177/07067437231194334
2017
Gargano, M. A., Matentzoglu, N., Coleman, B., Addo-Lartey, E. B., Anagnostopoulos, A. V., Anderton, J., Avillach, P., Bagley, A. M., Bakštein, E., Balhoff, J. P., Baynam, G., Bello, S. M., Berk, M., Bertram, H., Bishop, S., Blau, H., Bodenstein, D. F., Botas, P., Boztug, K., … Robinson, P. N. (2023). The Human Phenotype Ontology in 2024: phenotypes around the world. Nucleic Acids Research. https://doi.org/10.1093/nar/gkad1005
Gonzalez-Torres, C., Mulsant, B. H., Husain, M. I., Alda, M., Young, R. C., & Ortiz, A. (2023). Challenges in defining treatment-resistant mania in adults: A systematic review. Bipolar Disorders. https://doi.org/10.1111/bdi.13383
Ortiz, A., Park, Y., MacLean, S., Husain, M. I., Sanches, M., Ravindran, A., & Mulsant, B. H. (2023). A history of suicide attempt is associated with increased sympathetic activation in bipolar disorder. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie, 7067437231194334. https://doi.org/10.1177/07067437231194334
2016
Gargano, M. A., Matentzoglu, N., Coleman, B., Addo-Lartey, E. B., Anagnostopoulos, A. V., Anderton, J., Avillach, P., Bagley, A. M., Bakštein, E., Balhoff, J. P., Baynam, G., Bello, S. M., Berk, M., Bertram, H., Bishop, S., Blau, H., Bodenstein, D. F., Botas, P., Boztug, K., … Robinson, P. N. (2023). The Human Phenotype Ontology in 2024: phenotypes around the world. Nucleic Acids Research. https://doi.org/10.1093/nar/gkad1005
Gonzalez-Torres, C., Mulsant, B. H., Husain, M. I., Alda, M., Young, R. C., & Ortiz, A. (2023). Challenges in defining treatment-resistant mania in adults: A systematic review. Bipolar Disorders. https://doi.org/10.1111/bdi.13383
Ortiz, A., Park, Y., MacLean, S., Husain, M. I., Sanches, M., Ravindran, A., & Mulsant, B. H. (2023). A history of suicide attempt is associated with increased sympathetic activation in bipolar disorder. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie, 7067437231194334. https://doi.org/10.1177/07067437231194334